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JMV 449
CAS No. 139026-66-7
JMV 449( —— )
Catalog No. M30661 CAS No. 139026-66-7
Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameJMV 449
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NoteResearch use only, not for human use.
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Brief DescriptionPotent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.
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DescriptionPotent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo.
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In Vitro——
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In VivoJMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect. Animal Model:Male Swiss albino mice Dosage:120 pmol/mouse Administration:i.c.v.Result:Showed dose-response relation-ships for the analgesic effect.
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Synonyms——
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PathwayGPCR/G Protein
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TargetNeurotensin Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number139026-66-7
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Formula Weight746.96
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Molecular FormulaC38H66N8O7
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Purity>98% (HPLC)
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Solubilitywater:0.80 mg/mL
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SMILES[H]N[C@@H](CCCCN)CN[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lugrin et al (1991) Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 205 191 PMID:
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